Objective – This work intends to describe a case of sudden unexplained late fetal death at 41+4 gestational weeks, following physiological pregnancy, in which alterations of fetal adnexa were observed in association with congenital alterations of brainstem nuclei. Study design - The victim was subjected to in-depth anatomopathological examination, particularly of the central autonomic nervous system and of the placenta, following specific guidelines. Results - The histopahological study of the brainstem revealed hypoplasia of the arcuate nucleus in the medulla oblongata and hypoplasia of the parabrachial/Kölliker-Fuse complex in the pons/mesencephalon. The macroscopic examination of fetal adnexa showed absolute shortness of the umbilical cord (length 30 cm, maximum diameter 1.7 cm, minimum diameter 1 cm). Conclusion - The abnormally short umbilical cord observed in this case, although not enough to lead to sudden death, is likely to have triggered malignant effects, when coupled with severe developmental defects of the arcuate nucleus and of the parabrachial/Kölliker-Fuse complex

Absolute shortness of the umbilical cord and hypoplasia of the arcuate nucleus and of the parabrachial/Kölliker-Fuse complex in a case of sudden intrauterine fetal death / R. Mingrone, E. Fulcheri, A. M. Lavezzi, L. Matturri. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 147:1(2009), pp. 112-114. [10.1016/j.ejogrb.2009.07.004]

Absolute shortness of the umbilical cord and hypoplasia of the arcuate nucleus and of the parabrachial/Kölliker-Fuse complex in a case of sudden intrauterine fetal death

R. Mingrone
Primo
;
A. M. Lavezzi
Penultimo
;
L. Matturri
Ultimo
2009

Abstract

Objective – This work intends to describe a case of sudden unexplained late fetal death at 41+4 gestational weeks, following physiological pregnancy, in which alterations of fetal adnexa were observed in association with congenital alterations of brainstem nuclei. Study design - The victim was subjected to in-depth anatomopathological examination, particularly of the central autonomic nervous system and of the placenta, following specific guidelines. Results - The histopahological study of the brainstem revealed hypoplasia of the arcuate nucleus in the medulla oblongata and hypoplasia of the parabrachial/Kölliker-Fuse complex in the pons/mesencephalon. The macroscopic examination of fetal adnexa showed absolute shortness of the umbilical cord (length 30 cm, maximum diameter 1.7 cm, minimum diameter 1 cm). Conclusion - The abnormally short umbilical cord observed in this case, although not enough to lead to sudden death, is likely to have triggered malignant effects, when coupled with severe developmental defects of the arcuate nucleus and of the parabrachial/Kölliker-Fuse complex
Settore MED/08 - Anatomia Patologica
2009
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/68207
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact