Gold nanoparticles of two different sizes stabilised by a 15-mer peptide ligand specifically designed for this purpose have been prepared in aqueous solution and characterised by UV-vis spectroscopy and TEM. The presence of the ligand and its binding mode to the particles via its four cystein thiols is evidenced by FTIR and NMR spectroscopy. Biotinylation of the particles via binding to a freely accessible lysine residue is demonstrated.
A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles / Z. Krpetic, P. Nativo, F. Porta, M. Brust. - In: BIOCONJUGATE CHEMISTRY. - ISSN 1043-1802. - 20:3(2009), pp. 619-624.
A multidentate peptide for stabilization and facile bioconjugation of gold nanoparticles
Z. Krpetic;F. Porta;
2009
Abstract
Gold nanoparticles of two different sizes stabilised by a 15-mer peptide ligand specifically designed for this purpose have been prepared in aqueous solution and characterised by UV-vis spectroscopy and TEM. The presence of the ligand and its binding mode to the particles via its four cystein thiols is evidenced by FTIR and NMR spectroscopy. Biotinylation of the particles via binding to a freely accessible lysine residue is demonstrated.
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