Error-prone polymerases are alleged to induce mutations while replicating damaged DNA and to increase the risk of cancer. Using in vitro studies and mice models, Yoon et al. (2019) provide evidence that the error-prone Pol θ polymerase protects against ultraviolet light-induced skin cancer despite its mutagenic potential.
An Error-Prone Polymerase in the Fight against Cancer / Y.J. Achar, M. Foiani. - In: CELL. - ISSN 0092-8674. - 176:6(2019 Mar 07), pp. 1241-1243. [10.1016/j.cell.2019.02.011]
An Error-Prone Polymerase in the Fight against Cancer
M. Foiani
Ultimo
2019
Abstract
Error-prone polymerases are alleged to induce mutations while replicating damaged DNA and to increase the risk of cancer. Using in vitro studies and mice models, Yoon et al. (2019) provide evidence that the error-prone Pol θ polymerase protects against ultraviolet light-induced skin cancer despite its mutagenic potential.
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