The kinetics of naproxen, administered intravenously (IV) at doses of 3 and 10 mg.kg-1, was investigated in 4 healthy race-horses. The drug showed a short distribution half-life (<1 h) and a more prolonged elimination half-life (in the range 0f about 7 and 9 h) with both the doses. The values of Vd and of Vd(ss) evidentiated a good distributive capacity of naproxen, similarly to that of other NSAIDs administered in the horse. Proportional to the administered doses were also AUC values, in agreement with the value recorded by other Authors. In conclusion, the data obtained did not show a significant influence of the dose on drug’s kinetics.
Cinetica del naproxene nel cavallo sportivo : confronto preliminare tra due diversi livelli di dosaggio / S. Carli, P.A. Barili, R.E. Villa, P.P. Cagnardi, A. Zonca. - In: ATTI DELLA SOCIETÀ ITALIANA DELLE SCIENZE VETERINARIE. - ISSN 1825-4454. - 58:(2004), pp. 136 htm1-136 htm3. (Intervento presentato al 58. convegno Convegno Nazionale della Società Italiana delle Scienze Veterinarie tenutosi a Grado nel 2004).
Cinetica del naproxene nel cavallo sportivo : confronto preliminare tra due diversi livelli di dosaggio
S. CarliPrimo
;P.A. BariliSecondo
;R.E. Villa;P.P. CagnardiPenultimo
;A. ZoncaUltimo
2004
Abstract
The kinetics of naproxen, administered intravenously (IV) at doses of 3 and 10 mg.kg-1, was investigated in 4 healthy race-horses. The drug showed a short distribution half-life (<1 h) and a more prolonged elimination half-life (in the range 0f about 7 and 9 h) with both the doses. The values of Vd and of Vd(ss) evidentiated a good distributive capacity of naproxen, similarly to that of other NSAIDs administered in the horse. Proportional to the administered doses were also AUC values, in agreement with the value recorded by other Authors. In conclusion, the data obtained did not show a significant influence of the dose on drug’s kinetics.
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