Objectives: The present review summarizes epidemiological evidence on risk factors for thyroid cancer (TC), in particular, nutritional factors. Methods: Searches of articles on the issue were conducted using MEDLINE. Results: Exposure to ionizing radiation, particularly during childhood, is the best-established risk factor for TC. There is also a strong association with history of benign nodules/adenoma or goiter. Iodine deficiency may induce an increasing incidence of benign thyroid conditions, but very high iodine intake also affects thyroid function and, possibly, TC risk. Among dietary factors, fish-the major natural source of iodine in human diet-is not consistently related to TC risk. High intake of cruciferous vegetables shows a weak inverse association with TC. Among other food groups, vegetables other than cruciferous are the only food group showing a favorable effect on TC, with an approximate 20% reduction in risk for subjects with the highest consumption. No effect on TC risk of alcohol, coffee, or other food-groups/nutrients emerged. Height and weight at diagnosis show a moderate positive association with TC risk. Conclusion: At present, the only recognized measures for reducing TC risk is to avoid ionizing radiation and iodine deficiency, particularly in childhood and young women, and to increase vegetable consumption.
Risk factors for thyroid cancer : an epidemiological review focused on nutritional factors / L. Dal Maso, C. Bosetti, C. La Vecchia, S. Franceschi. - In: CANCER CAUSES & CONTROL. - ISSN 0957-5243. - 20:1(2009 Feb), pp. 75-86.
Risk factors for thyroid cancer : an epidemiological review focused on nutritional factors
C. La VecchiaPenultimo
;
2009
Abstract
Objectives: The present review summarizes epidemiological evidence on risk factors for thyroid cancer (TC), in particular, nutritional factors. Methods: Searches of articles on the issue were conducted using MEDLINE. Results: Exposure to ionizing radiation, particularly during childhood, is the best-established risk factor for TC. There is also a strong association with history of benign nodules/adenoma or goiter. Iodine deficiency may induce an increasing incidence of benign thyroid conditions, but very high iodine intake also affects thyroid function and, possibly, TC risk. Among dietary factors, fish-the major natural source of iodine in human diet-is not consistently related to TC risk. High intake of cruciferous vegetables shows a weak inverse association with TC. Among other food groups, vegetables other than cruciferous are the only food group showing a favorable effect on TC, with an approximate 20% reduction in risk for subjects with the highest consumption. No effect on TC risk of alcohol, coffee, or other food-groups/nutrients emerged. Height and weight at diagnosis show a moderate positive association with TC risk. Conclusion: At present, the only recognized measures for reducing TC risk is to avoid ionizing radiation and iodine deficiency, particularly in childhood and young women, and to increase vegetable consumption.File | Dimensione | Formato | |
---|---|---|---|
DalMaso2009_Article_RiskFactorsForThyroidCancerAnE.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
278.27 kB
Formato
Adobe PDF
|
278.27 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.