Histone deacetylases (HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and first-generation histone deacetylase inhibitors (HDACi) are currently being tested in phase I/II clinical trials. A wide-ranging knowledge of the role of HDACs in tumorigenesis, and of the action of HDACi, has been achieved. However, several basic aspects are not yet fully understood. Investigating these aspects in the context of what we now understand about HDACi action both in vitro and in vivo will further improve the design of optimized clinical protocols.

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer / S. Minucci, P.G. Pelicci. - In: NATURE REVIEWS CANCER. - ISSN 1474-175X. - 6:1(2006 Jan), pp. 38-51.

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

S. Minucci
Primo
;
P.G. Pelicci
Ultimo
2006

Abstract

Histone deacetylases (HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and first-generation histone deacetylase inhibitors (HDACi) are currently being tested in phase I/II clinical trials. A wide-ranging knowledge of the role of HDACs in tumorigenesis, and of the action of HDACi, has been achieved. However, several basic aspects are not yet fully understood. Investigating these aspects in the context of what we now understand about HDACi action both in vitro and in vivo will further improve the design of optimized clinical protocols.
acute myeloid-leukemia; acute promyelocytic leukemia; trans-retinoic acid; suberoylanilide hydroxamic acid ; metastasis-associated protein-1 ; oncogenic transcription factor ; t-cell lymphoma ; phase-i ; mediated apoptosis ; hdac inhibitors
Settore MED/04 - Patologia Generale
gen-2006
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/63043
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