Cells are continuously under the assault of endogenous and exogenous genotoxic stress that challenges the integrity of DNA. To cope with such a formidable task cells have evolved surveillance mechanisms, known as checkpoints, and a variety of DNA repair systems responding to different types of DNA lesions. These lesions occur in the context of the chromatin structure and, as expected for all DNA transactions, the cellular response to DNA damage is going to be influenced by the chromatin enviroment. In this review, we will discuss recent studies implicating chromatin remodelling factors and histone modifications in the response to DNA double-strand breaks (DSBs) and in checkpoint activation in response to UV lesions.

The interplay among chromatin dynamics, cell cycle checkpoints and repair mechanisms modulates the cellular response to DNA damage / F. Lazzaro, M. Giannattasio, M. Muzi Falconi, P. Plevani. - In: ITALIAN JOURNAL OF BIOCHEMISTRY. - ISSN 0021-2938. - 56:2(2007), pp. 141-148.

The interplay among chromatin dynamics, cell cycle checkpoints and repair mechanisms modulates the cellular response to DNA damage

F. Lazzaro
Primo
;
M. Giannattasio
Secondo
;
M. Muzi Falconi
Penultimo
;
P. Plevani
Ultimo
2007

Abstract

Cells are continuously under the assault of endogenous and exogenous genotoxic stress that challenges the integrity of DNA. To cope with such a formidable task cells have evolved surveillance mechanisms, known as checkpoints, and a variety of DNA repair systems responding to different types of DNA lesions. These lesions occur in the context of the chromatin structure and, as expected for all DNA transactions, the cellular response to DNA damage is going to be influenced by the chromatin enviroment. In this review, we will discuss recent studies implicating chromatin remodelling factors and histone modifications in the response to DNA double-strand breaks (DSBs) and in checkpoint activation in response to UV lesions.
No
English
DNA damage ; checkpoints ; chromatin ; cell cycle
Settore BIO/11 - Biologia Molecolare
Articolo
Sì, ma tipo non specificato
2007
Il Pensiero Scientifico
56
2
141
148
8
Pubblicato
Periodico con rilevanza internazionale
info:eu-repo/semantics/article
The interplay among chromatin dynamics, cell cycle checkpoints and repair mechanisms modulates the cellular response to DNA damage / F. Lazzaro, M. Giannattasio, M. Muzi Falconi, P. Plevani. - In: ITALIAN JOURNAL OF BIOCHEMISTRY. - ISSN 0021-2938. - 56:2(2007), pp. 141-148.
none
Prodotti della ricerca::01 - Articolo su periodico
4
262
Article (author)
no
F. Lazzaro, M. Giannattasio, M. Muzi Falconi, P. Plevani
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/62897
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