Despite the reducing incidence of chronic hepatitis infections, an unexpected increasing incidence of hepatocellular carcinoma (HCC) has being occurred. This may be explained by the increasing number of HCCs developing on steatosis (NAFLD) and steatohepatitis (NASH), related to metabolic risk factors (i.e. diabetes mellitus type II, obesity, metabolic syndrome), which are becoming emerging risk factors for HCC. This led to a growing scientific interest on the oncogenic mechanisms underlying the transition from NAFLD to HCC. However, patients with NASH receive significantly less HCC surveillance than patients with chronic hepatitis, and no specific preventive pharmacological treatments have recommended for NASH-related HCC. This review focuses on the pathogenic role of the emerging factors involved in the transition from NAFLD/NASH to HCC, including microbiota, insulin resistance, inflammation, lipid and bile acids metabolism. It will be emphasize their impact on the liver microenvironment, the implications in clinical practice and the future directions of research.
Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment / P. Agosti, C. Sabbà, A. Mazzocca. - In: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE. - ISSN 0925-4439. - 1864:2(2018), pp. 607-617.
|Titolo:||Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment|
|Parole Chiave:||Hepatocellular carcinoma (HCC); Inflammation; Insulin resistance; Liver microenvironment; Non-alcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Adipokines; Animals; Bile Acids and Salts; Carcinoma, Hepatocellular; Cellular Senescence; Fatty Liver; Humans; Inflammation; Insulin Resistance; Lipid Metabolism; Lipids; Liver; Liver Neoplasms; Non-alcoholic Fatty Liver Disease; Obesity; Phenotype; Precancerous Conditions; Prognosis; Risk Factors; Tumor Microenvironment; Molecular Medicine; Molecular Biology|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
Settore MED/05 - Patologia Clinica
Settore MED/06 - Oncologia Medica
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.bbadis.2017.11.026|
|Appare nelle tipologie:||01 - Articolo su periodico|