Myriocin (Myr) is a suicide inactivator of ceramide synthesis with a complex lipid multifunctional structure. Its biological activity is exerted at very low doses, and thus highly performing quantitative method are needed [1]. The pharmacological development of Myr to modulate ceramide levels also requires currently unavailable ADME information in healthy and pathological animal models.
Pharmacokinetic of myriocin in rabbit’s eyes / M. Dei Cas, F.M. Rubino, J. Rizzo, P. Signorelli, E. Strettoi, C. Platania, C. Bucolo, R. Pignatello, R. Ghidoni, R.C. Paroni - In: XXII International Mass Spectrometry Conference : abstract book / [a cura di] G. Giorgi. - Prima edizione. - Firenze : International Mass Spectrometry Foundation, 2018 Nov. - ISBN 9788890738852. - pp. 374-375 (( Intervento presentato al 22. convegno International mass spectrometry conference tenutosi a Firenze nel 2018.
Pharmacokinetic of myriocin in rabbit’s eyes
M. Dei CasPrimo
Membro del Collaboration Group
;F.M. RubinoSecondo
Membro del Collaboration Group
;J. RizzoMembro del Collaboration Group
;P. SignorelliMembro del Collaboration Group
;C. Platania;R. GhidoniPenultimo
;R.C. Paroni
Ultimo
2018
Abstract
Myriocin (Myr) is a suicide inactivator of ceramide synthesis with a complex lipid multifunctional structure. Its biological activity is exerted at very low doses, and thus highly performing quantitative method are needed [1]. The pharmacological development of Myr to modulate ceramide levels also requires currently unavailable ADME information in healthy and pathological animal models.
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