The patent relates to the prepn. of hyperbranched, water-sol. polymers, obtainable by Michael polyaddn. of alpha-, beta-, or gamma-cyclodextrins and amines. It also relates to the use of the title polymer as solubilizing agent for water insol. drugs. Thus, a Michael polyaddn. polymer obtained from a mixt. comprising 2,2-bis(acrylamido)acetic acid, beta-cyclodextrin, 2-methylpiperazine, and a small amt. of water was used to solubilize paclitaxel and showed 4.63 wt% of drug load
Hyperbranched polymers based on cyclodextrins and poly(amidoamines) for the controlled release of insoluble drugs / P. Ferruti, E. Ranucci, F. Trotta, R. Cavalli, C. Fernandez.
Hyperbranched polymers based on cyclodextrins and poly(amidoamines) for the controlled release of insoluble drugs
P. FerrutiPrimo
;E. RanucciSecondo
;
2008
Abstract
The patent relates to the prepn. of hyperbranched, water-sol. polymers, obtainable by Michael polyaddn. of alpha-, beta-, or gamma-cyclodextrins and amines. It also relates to the use of the title polymer as solubilizing agent for water insol. drugs. Thus, a Michael polyaddn. polymer obtained from a mixt. comprising 2,2-bis(acrylamido)acetic acid, beta-cyclodextrin, 2-methylpiperazine, and a small amt. of water was used to solubilize paclitaxel and showed 4.63 wt% of drug load
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