A couple of novel optically active diphosphine ligands, called DIOPHEP, has been designed and synthesized starting from a derivative of tartaric acid. The ligands conjugate the sp3 chirality of the precursor of DIOP with the atropisomeric chirality of a biaryl scaffold. The stereorecognition abilities of DIPHEP-Ru complex catalysts have been investigated in the asymmetric catalytic hydrogenation of some standard substrates suggesting a close relationship between dihedral angles and enantioselectivity.
DIOPHEP, a chiral diastereoisomer bisphosphine ligands : synthesis and applications in asymmetric hydrogenations / E. Cesarotti, G. Abbiati, E. Rossi, P. Spalluto, I. Rimoldi. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 19:14(2008 Jul 25), pp. 1654-1659. [10.1016/j.tetasy.2008.07.009]
DIOPHEP, a chiral diastereoisomer bisphosphine ligands : synthesis and applications in asymmetric hydrogenations
E. CesarottiPrimo
;G. AbbiatiSecondo
;E. Rossi;P. SpallutoPenultimo
;I. RimoldiUltimo
2008
Abstract
A couple of novel optically active diphosphine ligands, called DIOPHEP, has been designed and synthesized starting from a derivative of tartaric acid. The ligands conjugate the sp3 chirality of the precursor of DIOP with the atropisomeric chirality of a biaryl scaffold. The stereorecognition abilities of DIPHEP-Ru complex catalysts have been investigated in the asymmetric catalytic hydrogenation of some standard substrates suggesting a close relationship between dihedral angles and enantioselectivity.
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