Aim: Recent findings show that DNA methylation is susceptible to very preterm (VPT) birth and to the experience of the early stay in the neonatal intensive care unit. The aim of the study was to compare PLAGL1 methylation between VPT and full-term (FT) infants at birth as well as between VPT infants at discharge and FT infants at birth. Methods: DNA was collected from cord blood of 56 VPT and 27 FT infants at birth and from peripheral blood in VPT infants at neonatal intensive care unit discharge. Sociodemographic and neonatal variables were considered. Results:PLAGL1 methylation at birth and at discharge were highly correlated in VPT infants. Lower methylation emerged in VPT infants at birth and discharge compared to FT counterparts. Conclusion:PLAGL1 hypomethylation emerged as a potential epigenetic mark of VPT birth. Future research is warranted to assess the functional consequences of PLAGL1 diminished methylation in VPT infants’ development.
Very preterm birth is associated with PLAGL1 gene hypomethylation at birth and discharge / L. Provenzi, P.D. Carli, M. Fumagalli, R. Giorda, S. Casavant, S. Beri, A. Citterio, A. D'Agata, F. Morandi, F. Mosca, R. Borgatti, R. Montirosso. - In: EPIGENOMICS. - ISSN 1750-1911. - 10:8(2018 Aug), pp. 1121-1130. [10.2217/epi-2017-0123]
Very preterm birth is associated with PLAGL1 gene hypomethylation at birth and discharge
M. FumagalliInvestigation
;F. MoscaSupervision
;
2018
Abstract
Aim: Recent findings show that DNA methylation is susceptible to very preterm (VPT) birth and to the experience of the early stay in the neonatal intensive care unit. The aim of the study was to compare PLAGL1 methylation between VPT and full-term (FT) infants at birth as well as between VPT infants at discharge and FT infants at birth. Methods: DNA was collected from cord blood of 56 VPT and 27 FT infants at birth and from peripheral blood in VPT infants at neonatal intensive care unit discharge. Sociodemographic and neonatal variables were considered. Results:PLAGL1 methylation at birth and at discharge were highly correlated in VPT infants. Lower methylation emerged in VPT infants at birth and discharge compared to FT counterparts. Conclusion:PLAGL1 hypomethylation emerged as a potential epigenetic mark of VPT birth. Future research is warranted to assess the functional consequences of PLAGL1 diminished methylation in VPT infants’ development.File | Dimensione | Formato | |
---|---|---|---|
PLAGL1_revised_proof_adagata.pdf
accesso aperto
Tipologia:
Pre-print (manoscritto inviato all'editore)
Dimensione
735.93 kB
Formato
Adobe PDF
|
735.93 kB | Adobe PDF | Visualizza/Apri |
Fumagalli epigenomics 2018 - .pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
962.24 kB
Formato
Adobe PDF
|
962.24 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.