Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.

Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.

Old and new targets for innovative antimalarial compounds : the different strategies of the Italian Malaria Network / N. Basilico, E. Bosisio, F. Buelli, G. Campiani, M. Casagrande, F. Castelli, P. Coghi, Y. Corbett, L. Cortelezzi, S. D'Alessandro, M. Dell'Agli, F. Esposito, C. Fattorusso, E. Fattorusso, S. Finaurini, G.V. Galli, S. Gemma, A. Habluetzel, L. Lucantoni, S.R. Melato, D. Monti, P. Olliaro, M.F. Omodeo-Salè, S. Parapini, M. Persico, M. Rizzi, S. Romeo, F. Rossi, C. Rusconi, A. Sparatore, O.T. Scafati, E. van den Bogaart, D. Taramelli, N. Vaiana, S. Yerbanga. - In: PARASSITOLOGIA. - ISSN 0048-2951. - 50:1-2(2008), pp. 133-136. [No DOI is available for this article.]

Old and new targets for innovative antimalarial compounds : the different strategies of the Italian Malaria Network

N. Basilico;E. Bosisio;M. Casagrande;P. Coghi;Y. Corbett;L. Cortelezzi;S. D'Alessandro;M. Dell'Agli;S. Finaurini;S.R. Melato;M.F. Omodeo-Salè;S. Parapini;S. Romeo;C. Rusconi;A. Sparatore;D. Taramelli;N. Vaiana;
2008

Abstract

Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.
Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.
Settore BIO/10 - Biochimica
Settore MED/04 - Patologia Generale
Settore CHIM/08 - Chimica Farmaceutica
Settore BIO/15 - Biologia Farmaceutica
2008
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/57524
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact