New benzimidazole-based tetrapeptide mimics were synthesized and their conformational features were studied by NMR and molecular modeling techniques. All the analyses led to the conclusion that a β-turn is stabilized in both 2 and 3. Since values of the torsion angles do not allow an univocal definition of the β-turn type, structures 2 and 3 could be assigned to the generic type IV classification.
Synthesis and conformational analysis of benzimidazole-based reverse turn mimics / G. Lesma, A. Sacchetti, A. Silvani. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 49:8(2008), pp. 1293-1296.
Synthesis and conformational analysis of benzimidazole-based reverse turn mimics
G. LesmaPrimo
;A. SacchettiSecondo
;A. SilvaniUltimo
2008
Abstract
New benzimidazole-based tetrapeptide mimics were synthesized and their conformational features were studied by NMR and molecular modeling techniques. All the analyses led to the conclusion that a β-turn is stabilized in both 2 and 3. Since values of the torsion angles do not allow an univocal definition of the β-turn type, structures 2 and 3 could be assigned to the generic type IV classification.
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