We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Anidulafungin in combination with amphotericin B against Aspergillus fumigatus / E. Spreghini, F. Orlando, A. Santinelli, E. Pisa, C. Loretelli, E. Manso, M.E. Milici, G. Scalise, F. Barchiesi. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 53:9(2009), pp. 4035-4039. [10.1128/AAC.00659-09]
Anidulafungin in combination with amphotericin B against Aspergillus fumigatus
C. Loretelli;
2009
Abstract
We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug. Copyright © 2009, American Society for Microbiology. All Rights Reserved.File | Dimensione | Formato | |
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