We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Anidulafungin in combination with amphotericin B against Aspergillus fumigatus / E. Spreghini, F. Orlando, A. Santinelli, E. Pisa, C. Loretelli, E. Manso, M.E. Milici, G. Scalise, F. Barchiesi. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 53:9(2009), pp. 4035-4039. [10.1128/AAC.00659-09]

Anidulafungin in combination with amphotericin B against Aspergillus fumigatus

C. Loretelli;
2009

Abstract

We investigated the effects of anidulafungin alone and in combination with amphotericin B against Aspergillus fumigatus. Indifference was the only type of interaction observed in vitro. Anidulafungin at 1 and 5 mg/kg of body weight/day, amphotericin B at 1 mg/kg/day, and combination therapy prolonged the survival of mice with invasive aspergillosis. Anidulafungin at 5 mg/kg/day, alone and in combination with amphotericin B, reduced the kidney fungal burden. Overall, the combination was not superior to the most active single drug. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
amphotericin b; animals; antifungal agents; aspergillosis; aspergillus fumigatus; brain; drug therapy, combination; echinocandins; kidney; mice; microbial sensitivity tests; pharmacology; pharmacology (medical); infectious diseases
Settore MED/06 - Oncologia Medica
Settore MED/04 - Patologia Generale
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Settore BIO/13 - Biologia Applicata
Settore MED/03 - Genetica Medica
2009
Article (author)
File in questo prodotto:
File Dimensione Formato  
Anidulafungin in Combination with Amphotericin B against Aspergillus fumigatus.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 958.67 kB
Formato Adobe PDF
958.67 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/570277
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 14
social impact