Objective: To describe clinical, MRI and cerebrospinal fluid (CSF) features of a varicella zoster virus (VZV) related meningo-encephalo-myelitis (MEM) without rash in an immunocompetent female. Patient: An 85 year old immunocompetent woman with mild hyperthermia and acute, severe MEM. Intervention: Serum antibodies and CSF PCR were searched for several viruses. Brain and spinal cord MRI were performed. Immunological profile. Treatments: i.v. acyclovir 30 mg/kg/day; i.v. 6-MP 125 mg/day. Results: Marked CSF lymphomonocytic pleocytosis, blood-brainbarrier damage, and PCR detection of 3.05 X 10 6 copies of VZV DNA. MRI revealed lesions of the meninges, brain and spinal cord. No evidence of immunosuppression. Conclusion: We highlight the importance of considering the possibility of VZV related MEM, even in immunocompetent patients. We also provide a MRI description of VZV related multifocal myelitis, not previously available. As supported by other reports, we underline the necessity of a prompt therapeutic intervention in this life-threatening condition.

Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient / E. Tavazzi, L. Minoli, P. Ferrante, P. Scagnelli, S. Del Bue, A. Romani, S. Ravaglia, E. Marchioni. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 29:4(2008 Sep), pp. 279-283. [10.1007/s10072-008-0982-6]

Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient

P. Ferrante;S. Del Bue;
2008

Abstract

Objective: To describe clinical, MRI and cerebrospinal fluid (CSF) features of a varicella zoster virus (VZV) related meningo-encephalo-myelitis (MEM) without rash in an immunocompetent female. Patient: An 85 year old immunocompetent woman with mild hyperthermia and acute, severe MEM. Intervention: Serum antibodies and CSF PCR were searched for several viruses. Brain and spinal cord MRI were performed. Immunological profile. Treatments: i.v. acyclovir 30 mg/kg/day; i.v. 6-MP 125 mg/day. Results: Marked CSF lymphomonocytic pleocytosis, blood-brainbarrier damage, and PCR detection of 3.05 X 10 6 copies of VZV DNA. MRI revealed lesions of the meninges, brain and spinal cord. No evidence of immunosuppression. Conclusion: We highlight the importance of considering the possibility of VZV related MEM, even in immunocompetent patients. We also provide a MRI description of VZV related multifocal myelitis, not previously available. As supported by other reports, we underline the necessity of a prompt therapeutic intervention in this life-threatening condition.
English
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Sì, ma tipo non specificato
set-2008
Springer
29
4
279
283
Periodico con rilevanza internazionale
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18810606
info:eu-repo/semantics/article
Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient / E. Tavazzi, L. Minoli, P. Ferrante, P. Scagnelli, S. Del Bue, A. Romani, S. Ravaglia, E. Marchioni. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 29:4(2008 Sep), pp. 279-283. [10.1007/s10072-008-0982-6]
none
Prodotti della ricerca::01 - Articolo su periodico
8
262
Article (author)
Periodico con Impact Factor
E. Tavazzi, L. Minoli, P. Ferrante, P. Scagnelli, S. Del Bue, A. Romani, S. Ravaglia, E. Marchioni
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/54378
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 30
  • ???jsp.display-item.citation.isi??? 24
social impact