Synthetic transformations of natural nucleosides and carbocyclic or acyclic analogues require careful choice of methods for introduction/removal of suitable protecting groups. Problems related to chemo-, regio- and stereoselectivity of such transformations, a particularly relevant aspect in nucleoside chemistry, can be adequately solved using a biocatalytic approach. This chapter will illustrate the state of the art in the enzyme-assisted protection/deprotection procedures either in a hydrolytic mode or taking advantage of reactions that can be carried out in organic solvents by suitable lipases.
Enzyme-assisted introduction and cleavage of protecting groups in nucleoside chemistry / E. Santaniello, L. Alessandrini, P. Ciuffreda - In: Biocatalysis : chemistry and biochemistry / A. Trincone. - Kerala : Research Sigpost, 2005. - ISBN 81-7736-286-0. - pp. 1-27
Enzyme-assisted introduction and cleavage of protecting groups in nucleoside chemistry
E. SantanielloPrimo
;L. AlessandriniSecondo
;P. CiuffredaUltimo
2005
Abstract
Synthetic transformations of natural nucleosides and carbocyclic or acyclic analogues require careful choice of methods for introduction/removal of suitable protecting groups. Problems related to chemo-, regio- and stereoselectivity of such transformations, a particularly relevant aspect in nucleoside chemistry, can be adequately solved using a biocatalytic approach. This chapter will illustrate the state of the art in the enzyme-assisted protection/deprotection procedures either in a hydrolytic mode or taking advantage of reactions that can be carried out in organic solvents by suitable lipases.Pubblicazioni consigliate
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