Asymmetrization of prochiral 2-methylpropane-1,3-diol by Mucor miehei lipase (MML)-catalyzed acylation with vinyl benzoate affords the corresponding (S)-monobenzoate (65% ee), which can be obtained enantiomerically pure in 40% yield from a sequential benzoylation procedure at 58% conversion of the diol to the corresponding dibenzoate.
Asymmetrization of 2-methylpropane-1,3-diol by Mucor miehei lipase-catalyzed benzoylation in organic solvent / E. Santaniello, S. Casati, P. Ciuffreda, L. Gamberoni. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 15:20(2004), pp. 3177-3179. [10.1016/j.tetasy.2004.09.005]
Asymmetrization of 2-methylpropane-1,3-diol by Mucor miehei lipase-catalyzed benzoylation in organic solvent
E. SantanielloPrimo
;S. CasatiSecondo
;P. CiuffredaPenultimo
;
2004
Abstract
Asymmetrization of prochiral 2-methylpropane-1,3-diol by Mucor miehei lipase (MML)-catalyzed acylation with vinyl benzoate affords the corresponding (S)-monobenzoate (65% ee), which can be obtained enantiomerically pure in 40% yield from a sequential benzoylation procedure at 58% conversion of the diol to the corresponding dibenzoate.
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