Small-diameter nervefibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nervefibers, as assessed by the quantification of intra-epidermal nervefiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.
Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy / R. Bianchi, R. Lombardi, C. PORRETTA SERAPIGLIA, G. LAURIA PINTER (METHODS IN MOLECULAR BIOLOGY). - In: Tissue-Protective Cytokines : Methods and Protocols / [a cura di] P. Ghezzi, A. Cerami. - [s.l] : Humana Press Inc., 2013. - ISBN 9781627033077. - pp. 197-211 [10.1007/978-1-62703-308-4_13]
Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy
C. PORRETTA SERAPIGLIA;G. LAURIA PINTER
2013
Abstract
Small-diameter nervefibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nervefibers, as assessed by the quantification of intra-epidermal nervefiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.File | Dimensione | Formato | |
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