Objectives: Since a relation between trans-fatty acids and cardiovascular diseases has been described, we examined the relationship between margarine intake and nonfatal acute myocardial infarction (AMI) in Italian women. Design: Hospital-based case-control study. Setting: Northern Italy between 1983 and 1992. Subjects: Cases were 429 women, aged 18–74 y, in hospital with diagnosis of AMI and 866 controls in hospital for acute, non-cardiovascular, non-neoplastic, non-digestive, non-hormone-related conditions. Analysis: Odds ratios (OR), with their 95% confidence intervals (CI), were computed by unconditional multiple logistic regression analysis, including terms for age, education, body mass index, smoking, alcohol and coffee drinking, menopausal status, hormone replacement therapy and history of diabetes, hypertension and hyperlipidemia. Results: Medium or high intake of margarine was associated with an increased risk of AMI (multivariate OR 1.5, 95% CI 1.0–2.2). Analysis in separate strata of covariates indicated that the association was independent of body mass index, history of hypertension and hyperlipidemia, and was greater in older women and in current smokers. Conclusions: If real, the association with margarine could explain about 6% of AMI in this population of Italian women.

Margarine intake and risk of nonfatal acute myocardial infarction in Italian women / A. Tavani, E. Negri, B. D'Avanzo, C. La Vecchia. - In: EUROPEAN JOURNAL OF CLINICAL NUTRITION. - ISSN 0954-3007. - 51:1(1997 Jan), pp. 30-32.

Margarine intake and risk of nonfatal acute myocardial infarction in Italian women

E. Negri
Secondo
;
C. La Vecchia
Ultimo
1997

Abstract

Objectives: Since a relation between trans-fatty acids and cardiovascular diseases has been described, we examined the relationship between margarine intake and nonfatal acute myocardial infarction (AMI) in Italian women. Design: Hospital-based case-control study. Setting: Northern Italy between 1983 and 1992. Subjects: Cases were 429 women, aged 18–74 y, in hospital with diagnosis of AMI and 866 controls in hospital for acute, non-cardiovascular, non-neoplastic, non-digestive, non-hormone-related conditions. Analysis: Odds ratios (OR), with their 95% confidence intervals (CI), were computed by unconditional multiple logistic regression analysis, including terms for age, education, body mass index, smoking, alcohol and coffee drinking, menopausal status, hormone replacement therapy and history of diabetes, hypertension and hyperlipidemia. Results: Medium or high intake of margarine was associated with an increased risk of AMI (multivariate OR 1.5, 95% CI 1.0–2.2). Analysis in separate strata of covariates indicated that the association was independent of body mass index, history of hypertension and hyperlipidemia, and was greater in older women and in current smokers. Conclusions: If real, the association with margarine could explain about 6% of AMI in this population of Italian women.
adolescent; adult; age factors; aged; case-control studies; educational status; female; humans; Italy; margarine; middle aged; myocardial infarction; odds ratio; risk factors; smoking
Settore MED/01 - Statistica Medica
gen-1997
Article (author)
File in questo prodotto:
File Dimensione Formato  
1600356a.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 51.88 kB
Formato Adobe PDF
51.88 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/519251
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 12
social impact