The cDNA of the Sprague-Dawley rat estrogen receptor was sequenced. With respect to the published Wistar rat estrogen receptor sequence, a single amino acid difference (tryptophan instead of asparagine) was found in the hormone binding site. Since tryptophan was found at the same position in chicken, human and mouse estrogen receptors, it is proposed that the Wistar rat could represent an interesting natural mutant for estrogen receptor studies.
Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley rat / E. Spreafico, E. Bettini, G. Pollio, A. Maggi. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 227:3(1992 Nov 02), pp. 353-356. [10.1016/0922-4106(92)90016-O]
Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley rat
G. PollioPenultimo
;A. MaggiUltimo
1992
Abstract
The cDNA of the Sprague-Dawley rat estrogen receptor was sequenced. With respect to the published Wistar rat estrogen receptor sequence, a single amino acid difference (tryptophan instead of asparagine) was found in the hormone binding site. Since tryptophan was found at the same position in chicken, human and mouse estrogen receptors, it is proposed that the Wistar rat could represent an interesting natural mutant for estrogen receptor studies.
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