Deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from [2,2,3,4,4,6-H-2(6)]-cholesterol and (20S)-[7,7,21,21-H-2(4)]-3beta-(tert-butyldimethylsilyl)oxy-20-methylpregna-5-en-21-ol, respectively.
Synthesis of deuterated isotopomers of 7 alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids. / P. Ciuffreda, S. Casati, L. Alessandrini, G. Terraneo, E. Santaniello. - In: STEROIDS. - ISSN 0039-128X. - 68:9(2003), pp. 733-738.
Synthesis of deuterated isotopomers of 7 alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids.
P. CiuffredaPrimo
;S. CasatiSecondo
;L. Alessandrini;G. TerraneoPenultimo
;E. SantanielloUltimo
2003
Abstract
Deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from [2,2,3,4,4,6-H-2(6)]-cholesterol and (20S)-[7,7,21,21-H-2(4)]-3beta-(tert-butyldimethylsilyl)oxy-20-methylpregna-5-en-21-ol, respectively.
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