The ability of 4-(1,2-diphenylbut-1-en-1-yl)aniline as a self-assembly inducer is reported. The conjugation of this moiety with aloin or podophyllotoxin resulted in spherical nanoparticles that were characterized by Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and NanoSight technology. A preliminary biological evaluation on two cancer cell lines is reported.

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks / G. Fumagalli, M.S. Christodoulou, B. Riva, I. Revuelta, C. Marucci, V. Collico, D. Prosperi, S. Riva, D. Perdicchia, I. Bassanini, A. García Argáez, L.D. Via, D. Passarella. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 15:5(2017 Feb 07), pp. 1106-1109. [10.1039/c6ob02591a]

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

G. Fumagalli;M.S. Christodoulou;C. Marucci;S. Riva;D. Perdicchia;I. Bassanini;D. Passarella
2017-02-07

Abstract

The ability of 4-(1,2-diphenylbut-1-en-1-yl)aniline as a self-assembly inducer is reported. The conjugation of this moiety with aloin or podophyllotoxin resulted in spherical nanoparticles that were characterized by Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and NanoSight technology. A preliminary biological evaluation on two cancer cell lines is reported.
Drug-delivery; therapy; size; diagnostics; paclitaxel; protein
Settore CHIM/06 - Chimica Organica
ORGANIC & BIOMOLECULAR CHEMISTRY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/500250
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