Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell < or = 200; HIV-RNA < or = 50) compared with 11 full responders (CD4+ T-cell > or= 400; HIV-RNA < or = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy / G. Marchetti, G.M. Bellistrì, E. Borghi, C. Tincati, S. Ferramosca, M. La Francesca, G. Morace, A. Gori, A. D'Arminio Monforte. - In: AIDS. - ISSN 0269-9370. - 22:15(2008 Oct 01), pp. 2035-2038. (Intervento presentato al 15. convegno Conference on Retroviruses and Opportunistic Infections tenutosi a Boston nel 2008) [10.1097/QAD.0b013e3283112d29].

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

G. Marchetti
;
G.M. Bellistrì
Secondo
;
E. Borghi;C. Tincati;S. Ferramosca;M. La Francesca;G. Morace;A. Gori;A. D'Arminio Monforte
Ultimo
2008

Abstract

Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell < or = 200; HIV-RNA < or = 50) compared with 11 full responders (CD4+ T-cell > or= 400; HIV-RNA < or = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.
bacterial translocation; activation; pathogenesis; individuals; trurnover; recovery; disease; cohort; haart; count
Settore MED/17 - Malattie Infettive
Settore MED/07 - Microbiologia e Microbiologia Clinica
1-ott-2008
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/45915
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