34 pubertal children with constitutional growth delay (CGD) were treated with clonidine orally twice a day. In 25 of the children the height velocity rose on clonidine treatment, and in 21 of them by more than 2 cm/yr during the first 6 months of treatment (mean [SD] growth increment 4·4 [0·5] cm/yr). Of the 22 who were treated for 12 months the increment in height velocity was maintained in 13 (3·4 [0·4] cm/yr). Withdrawal of clonidine for 6 months did not stop the stimulatory effect of the drug on linear growth in 6 children, but in the other 8 children height velocities fell to pretreatment levels or below. In a few children reinstitution of clonidine for 2-4 months resulted in a new increment in height velocity. A high height standard deviation score and low growth velocity before treatment were predictive of a good growth response to clonidine. Clonidine did not induce noticeable side-effects. It may be a useful form of therapy for children with CGD.
Clonidine treatment for short stature / C. Pintor, S. Loche, R. Corda, S. Cella, R. Puggioni, V. Locatelli, E. Müller. - In: THE LANCET. - ISSN 0140-6736. - 329:8544(1987), pp. 1226-1230. [10.1016/S0140-6736(87)92684-5]
Clonidine treatment for short stature
S. Cella;
1987
Abstract
34 pubertal children with constitutional growth delay (CGD) were treated with clonidine orally twice a day. In 25 of the children the height velocity rose on clonidine treatment, and in 21 of them by more than 2 cm/yr during the first 6 months of treatment (mean [SD] growth increment 4·4 [0·5] cm/yr). Of the 22 who were treated for 12 months the increment in height velocity was maintained in 13 (3·4 [0·4] cm/yr). Withdrawal of clonidine for 6 months did not stop the stimulatory effect of the drug on linear growth in 6 children, but in the other 8 children height velocities fell to pretreatment levels or below. In a few children reinstitution of clonidine for 2-4 months resulted in a new increment in height velocity. A high height standard deviation score and low growth velocity before treatment were predictive of a good growth response to clonidine. Clonidine did not induce noticeable side-effects. It may be a useful form of therapy for children with CGD.Pubblicazioni consigliate
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