AIMS: To contribute to the understanding of the role played by CMV in sustaining monocyte/macrophage-mediated immune activation in ART treated HIV infected subjects. DESIGN: and Methods: We selected 23 CMV-uninfected and 46 CMV-infected HIV+ subjects, matched for age, CD4 nadir, HIV infection duration, viral hepatitis serostatus. All subjects were on successful ART since at least 1 year. A group of 16 healthy donors with similar age and sex was also included. Plasma levels of TNF-α, IL-6, sCD163, sCD14 and CMV IgG levels were measured in duplicate with human ELISA kits. RESULTS: We found significantly higher sCD163 plasma levels in HIV+CMV+ compared to HIV+CMV- subjects and healthy donors. This augmentation was confirmed also when HCV-Ab positive subjects were excluded from analysis. Interestingly a correlation between anti-CMV IgG levels and sCD163, TNF-α, IL-6 and sCD14 in HIV+CMV+ subjects was found. CONCLUSIONS: CMV co-infection could be a major driver of monocyte/macrophage activation in virally suppressed HIV+ individuals, and might explain the increased risk of non-AIDS morbidity/mortality in HIV/CMV coinfected subjects.

Soluble CD163 in CMV Infected and Uninfected subjects on Virologically-Suppressive Antiretroviral therapy in the ICONA cohort / S. Vita, M. Lichtner, G. Marchetti, C. Mascia, E. Merlini, P. Cicconi, V. Vullo, P. Viale, A. Costantini, A. DʼArminio Monforte. - In: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. - ISSN 1525-4135. - (2016). [Epub ahead of print] [10.1097/QAI.0000000000001232]

Soluble CD163 in CMV Infected and Uninfected subjects on Virologically-Suppressive Antiretroviral therapy in the ICONA cohort

G. Marchetti;E. Merlini;P. Cicconi;A. DʼArminio Monforte
Ultimo
2016

Abstract

AIMS: To contribute to the understanding of the role played by CMV in sustaining monocyte/macrophage-mediated immune activation in ART treated HIV infected subjects. DESIGN: and Methods: We selected 23 CMV-uninfected and 46 CMV-infected HIV+ subjects, matched for age, CD4 nadir, HIV infection duration, viral hepatitis serostatus. All subjects were on successful ART since at least 1 year. A group of 16 healthy donors with similar age and sex was also included. Plasma levels of TNF-α, IL-6, sCD163, sCD14 and CMV IgG levels were measured in duplicate with human ELISA kits. RESULTS: We found significantly higher sCD163 plasma levels in HIV+CMV+ compared to HIV+CMV- subjects and healthy donors. This augmentation was confirmed also when HCV-Ab positive subjects were excluded from analysis. Interestingly a correlation between anti-CMV IgG levels and sCD163, TNF-α, IL-6 and sCD14 in HIV+CMV+ subjects was found. CONCLUSIONS: CMV co-infection could be a major driver of monocyte/macrophage activation in virally suppressed HIV+ individuals, and might explain the increased risk of non-AIDS morbidity/mortality in HIV/CMV coinfected subjects.
monocyte/macrophage activation; HIV/CMV coinfected; sCD163
Settore MED/17 - Malattie Infettive
2016
4-nov-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/451306
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