Purpose: The aim of this study was to evaluate the feasibility of percutaneous transthoracic needle biopsy of pulmonary nodules under cone-beam computed tomography (CBCT) with “XperGuide” navigation guidance.Materials and methods: From February 2010 to January 2012, 100 patients (63 men and 37 women; mean age 67.27 years; range 21–88 years) with 100 lung nodules (44 ≤ 3 cm, 56 > 3 cm) underwent CBCT-XperGuide guided percutaneous transthoracic needle biopsies. Technical success, diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and complications were evaluated.Results: Of 100 nodules (mean size 5.19 cm), 68 were diagnosed as malignant, 27 as benign, and five as indeterminate. Technical success was 95 %. Only 33 of 100 patients underwent surgery: the final pathological diagnosis was concordant with the biopsy diagnosis in 26 cases and discordant in 7 cases (false negatives). Accuracy, sensitivity, specificity, PPV and NPV were 92.6, 90.9, 100, 100 and 72 %, respectively.Conclusions: CBCT-XperGuide navigation is a new, accurate and safe imaging guidance for percutaneous lung biopsies.

C-arm cone-beam computed tomography needle path overlay for percutaneous biopsy of pulmonary nodules / C. Floridi, A. Muollo, F. Fontana, N. Rotolo, A.M. Ierardi, E. Duka, C. Pellegrino, G. Carrafiello. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 119:11(2014), pp. 820-827. [10.1007/s11547-014-0406-z]

C-arm cone-beam computed tomography needle path overlay for percutaneous biopsy of pulmonary nodules

C. Floridi;N. Rotolo;G. Carrafiello
Ultimo
2014

Abstract

Purpose: The aim of this study was to evaluate the feasibility of percutaneous transthoracic needle biopsy of pulmonary nodules under cone-beam computed tomography (CBCT) with “XperGuide” navigation guidance.Materials and methods: From February 2010 to January 2012, 100 patients (63 men and 37 women; mean age 67.27 years; range 21–88 years) with 100 lung nodules (44 ≤ 3 cm, 56 > 3 cm) underwent CBCT-XperGuide guided percutaneous transthoracic needle biopsies. Technical success, diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and complications were evaluated.Results: Of 100 nodules (mean size 5.19 cm), 68 were diagnosed as malignant, 27 as benign, and five as indeterminate. Technical success was 95 %. Only 33 of 100 patients underwent surgery: the final pathological diagnosis was concordant with the biopsy diagnosis in 26 cases and discordant in 7 cases (false negatives). Accuracy, sensitivity, specificity, PPV and NPV were 92.6, 90.9, 100, 100 and 72 %, respectively.Conclusions: CBCT-XperGuide navigation is a new, accurate and safe imaging guidance for percutaneous lung biopsies.
C-arm cone-beam CT; Percutaneous lung biopsy; Pulmonary nodule
Settore MED/36 - Diagnostica per Immagini e Radioterapia
2014
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/431876
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