Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remains ill defined. Now, new data provide a straightforward mechanism for this latter function, as NPM is shown to regulate the stability and the function of MYC. Remarkably, the same leitmotif of "placing a critical cell regulator in the wrong place at the wrong time" appears to underscore all the cancer-promoting activities of mutated NPM.
Playing both sides : nucleophosmin between tumor suppression and oncogenesis / P.P. Di Fiore. - In: THE JOURNAL OF CELL BIOLOGY. - ISSN 0021-9525. - 182:1(2008 Jul 14), pp. 7-9. [10.1083/jcb.200806069]
Playing both sides : nucleophosmin between tumor suppression and oncogenesis
P.P. Di FiorePrimo
2008
Abstract
Nucleophosmin (NPM) is frequently mutated in acute myeloid leukemias and is thought to act as both a proto-oncogene and a tumor suppressor. Although genetic and molecular evidence has shed light on the mechanisms of NPM-mediated tumor suppression, the potential role of NPM mutants as oncogenes remains ill defined. Now, new data provide a straightforward mechanism for this latter function, as NPM is shown to regulate the stability and the function of MYC. Remarkably, the same leitmotif of "placing a critical cell regulator in the wrong place at the wrong time" appears to underscore all the cancer-promoting activities of mutated NPM.Pubblicazioni consigliate
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