Background: In addition to LDL-C, a growing body of evidence suggests that ApoB, non-HDL-C and CRP are predictive of CHD risk. This post-hoc analysis evaluates the % of patients who attained LDL-C<70mg/dL and specific levels of these other or emerging risk factors. Methods: This was a double-blind, 6-week, parallel group trial of hypercholesterolemic patients randomized to ezetimibe/simvastatin (E/S:10/20, 10/40, 10/80mg) or rosuvastatin (R:10, 20, 40mg), treatment comparisons between usual starting, next highest, maximum doses, and averaged across doses. Results: Baseline characteristics were similar among groups. At most dose comparisons, a significantly higher % of patients receiving E/S vs. R achieved LDL-C<70 mg/dL and the specified levels of the other or emerging risk factors, both individually and in combination with the LDL-C goal. Exceptions were no significant treatment differences for ApoB<90mg/dL and (non-HDL-C<100mg/dL + LDL-C<70mg/dL) when comparing E/S 10/40mg vs. R 20mg, and none for CRP<2.0mg/L at all dose comparisons. See table for comparison of combined dose groups. Conclusion: The potentially greater efficacy of E/S compared with R extends to modifications of some other and emerging risk factors. Ultimate clinical implications of these findings still need to be defined
Effects of ezetimibe/simvastatin vs. rosuvastatin on lowering of LDL-cholesterol as well as Apo-lipoprotein B, non-HDL-cholesterol, or C-reactive protein / C. Ballantyne, M.H. Davidson, A.L. Catapano, X. Xu, E. Rosenberg, A.M. Tershakovec. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 8:1(2007 Jun), pp. 201-201. (Intervento presentato al 76. convegno EAS congress tenutosi a Helsinki nel 2007) [10.1016/S1567-5688(07)71766-X].
Effects of ezetimibe/simvastatin vs. rosuvastatin on lowering of LDL-cholesterol as well as Apo-lipoprotein B, non-HDL-cholesterol, or C-reactive protein
A.L. Catapano;
2007
Abstract
Background: In addition to LDL-C, a growing body of evidence suggests that ApoB, non-HDL-C and CRP are predictive of CHD risk. This post-hoc analysis evaluates the % of patients who attained LDL-C<70mg/dL and specific levels of these other or emerging risk factors. Methods: This was a double-blind, 6-week, parallel group trial of hypercholesterolemic patients randomized to ezetimibe/simvastatin (E/S:10/20, 10/40, 10/80mg) or rosuvastatin (R:10, 20, 40mg), treatment comparisons between usual starting, next highest, maximum doses, and averaged across doses. Results: Baseline characteristics were similar among groups. At most dose comparisons, a significantly higher % of patients receiving E/S vs. R achieved LDL-C<70 mg/dL and the specified levels of the other or emerging risk factors, both individually and in combination with the LDL-C goal. Exceptions were no significant treatment differences for ApoB<90mg/dL and (non-HDL-C<100mg/dL + LDL-C<70mg/dL) when comparing E/S 10/40mg vs. R 20mg, and none for CRP<2.0mg/L at all dose comparisons. See table for comparison of combined dose groups. Conclusion: The potentially greater efficacy of E/S compared with R extends to modifications of some other and emerging risk factors. Ultimate clinical implications of these findings still need to be definedPubblicazioni consigliate
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