Preliminary results of an original approach to 4-substituted-2-phenylimidazoles starting from readily available N-propargyl-benzamidine and aryl halides are reported. Best yields were obtained using aryl halides bearing an electron-withdrawing group. Plausible mechanisms are also discussed.
Palladium catalyzed synthesis of 4-substituted-2-phenylimidazoles from N-propargyl-benzamidine / G. Abbiati, A. Arcadi, V. Canevari, E. Rossi. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 48:48(2007), pp. 8491-8495. [10.1016/j.tetlet.2007.09.153]
Palladium catalyzed synthesis of 4-substituted-2-phenylimidazoles from N-propargyl-benzamidine
G. Abbiati
Primo
;V. CanevariPenultimo
;E. RossiUltimo
2007
Abstract
Preliminary results of an original approach to 4-substituted-2-phenylimidazoles starting from readily available N-propargyl-benzamidine and aryl halides are reported. Best yields were obtained using aryl halides bearing an electron-withdrawing group. Plausible mechanisms are also discussed.
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