Uso della Claritromicina RM in chirurgia orale : studio comparativo

Polymicrobial oral infections are influenced by anatomy and histology of oral cavity, interactions with external environment and mutual relationships among resident microbial species. The knowledge of pathological mechanisms, pathogens location and epidemiological data about antibiotic resistance may support empirical planning of antibiotic therapy. A wide spectrum together with favourable pharmacokinetics, oral tissue tropism and good tolerance are the main selective criteria to choose antibacterial drugs. Aim of this preliminary study is a retrospective evaluation of wound healing and tolerance in three groups of patients submitted to oral biopsies. Patients were divided according to their risk (systemic, local, operative) and the therapeutic effects of clarithromycin RM were compared with amoxicillin-clavulanic acid and a placebo. The preliminary results showed good tolerance and considerable improvement in wound healing in the clarithromycin RM group. Clinical implications of these data suggest a widening of antibacterial drug options facing increasing bacterial resistance and individual sensibilization to antibiotics.