Stearoyl CoA desaturase (SCD) is the key enzyme involved in the endogenous synthesis of conjugated linoleic acid (CLA) in ruminants. Changes in the enzymatic activity as a result of SCD gene polymorphism and regulation have been hypothesized to cause diet-independent variations of CLA content in milk. Evidences for the direct influence of SCD polymorphism on fatty acid composition of milk and beef have also been reported. To evaluate genetic differences because of breed and/or selection goal, we investigated the polymorphism of three previously reported single nucleotide polymorphisms located in exon 5 of the SCD gene in 11 cattle breeds raised in Italy and selected for different production goals. Results obtained: (i) evidenced a high variability in the allele frequencies across breeds; (ii) detected three novel haplotypes, one of which is private to indigenous beef breeds, and (iii) showed a significant association between haplotypes and selective goal.

Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds / E. Milanesi, L. Nicoloso, P. Crepaldi. - In: JOURNAL OF ANIMAL BREEDING AND GENETICS. - ISSN 0931-2668. - 125:1(2008 Feb), pp. 63-67.

Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds

E. Milanesi
Primo
;
L. Nicoloso
Secondo
;
P. Crepaldi
2008

Abstract

Stearoyl CoA desaturase (SCD) is the key enzyme involved in the endogenous synthesis of conjugated linoleic acid (CLA) in ruminants. Changes in the enzymatic activity as a result of SCD gene polymorphism and regulation have been hypothesized to cause diet-independent variations of CLA content in milk. Evidences for the direct influence of SCD polymorphism on fatty acid composition of milk and beef have also been reported. To evaluate genetic differences because of breed and/or selection goal, we investigated the polymorphism of three previously reported single nucleotide polymorphisms located in exon 5 of the SCD gene in 11 cattle breeds raised in Italy and selected for different production goals. Results obtained: (i) evidenced a high variability in the allele frequencies across breeds; (ii) detected three novel haplotypes, one of which is private to indigenous beef breeds, and (iii) showed a significant association between haplotypes and selective goal.
bovine; conjugated linoleic acid; milk and meat quality; SNP
Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico
feb-2008
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/35501
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