Electrospun polycaprolactone (PCL) layers with sub-micron fibres arranged in random, semi-aligned and aligned manners were prepared and their anisotropic mechanical property were further characterised at various stretching angle. Proof of principle study was carried out to assess biocompatibility of electrospun layers with human mesenchymal stem cells (hMSCs). Cell adhesion, viability and orientation outcomes showed that aligned PCL nano-fibers can be applied as a template to guide the alignment of hMSCs and could be a promising scaffold for tissue engineering of anisotropic annulus fibrosus in spinal inter-vertebral disc.
Electrospun polycaprolactone nano-fibers support growth of human mesenchymal stem cells / A. Fotticchia, Y. Liu, E. Demirci, C. Lenardi. - In: PROCEEDINGS OF THE ... IEEE CONFERENCE ON NANOTECHNOLOGY. - ISSN 1944-9399. - (2013), pp. 6720851.158-6720851.161. ((Intervento presentato al convegno 2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013 tenutosi a Beijing, chn nel 2013.
Electrospun polycaprolactone nano-fibers support growth of human mesenchymal stem cells
C. LenardiUltimo
2013
Abstract
Electrospun polycaprolactone (PCL) layers with sub-micron fibres arranged in random, semi-aligned and aligned manners were prepared and their anisotropic mechanical property were further characterised at various stretching angle. Proof of principle study was carried out to assess biocompatibility of electrospun layers with human mesenchymal stem cells (hMSCs). Cell adhesion, viability and orientation outcomes showed that aligned PCL nano-fibers can be applied as a template to guide the alignment of hMSCs and could be a promising scaffold for tissue engineering of anisotropic annulus fibrosus in spinal inter-vertebral disc.Pubblicazioni consigliate
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