Purine nucleosides that are modified in the base or the furanose moiety and carbocyclonucleosides or acyclonucleosides often present antiviral activity. Their preparation can involve biocatalytic procedures, including use of deaminating enzymes of the purine cycle such as adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA). These enzymes, that are able to catalyze the hydrolytic deamination of various purine nucleosides and analogues, can be actually considered as valuable biocatalysts in nucleoside chemistry. Applications to the chemo-enzymatic preparation and transformation of compounds endowed with antiviral activity will be reviewed and discussed.
Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemo-enzymatic Synthesis and Transformation of Antiviral Agents Structurally Related to Purine Nucleosides / E. Santaniello, P. Ciuffreda, L. Alessandrini - In: Biocatalysis in the Pharmaceutical and Biotechnology Industries / [a cura di] Ramesh N. Patel. - Boca Raton : CRC Press, Taylor & Francis Group, 2007. - ISBN 9780849337321. - pp. 501-528
Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemo-enzymatic Synthesis and Transformation of Antiviral Agents Structurally Related to Purine Nucleosides
E. SantanielloPrimo
;P. CiuffredaSecondo
;L. AlessandriniUltimo
2007
Abstract
Purine nucleosides that are modified in the base or the furanose moiety and carbocyclonucleosides or acyclonucleosides often present antiviral activity. Their preparation can involve biocatalytic procedures, including use of deaminating enzymes of the purine cycle such as adenosine deaminase (ADA) and adenylic acid deaminase (AMPDA). These enzymes, that are able to catalyze the hydrolytic deamination of various purine nucleosides and analogues, can be actually considered as valuable biocatalysts in nucleoside chemistry. Applications to the chemo-enzymatic preparation and transformation of compounds endowed with antiviral activity will be reviewed and discussed.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.