This review summarizes the current understanding of the role of sphingolipid biosynthesis in the pathobiology of cryptococcosis, focusing on the production and functions of the antigenic glycosphingolipid (GSL) glucosylceramide (GlcCer) and its role in the host-pathogen interaction. In addition, the presence of GlcCer and structurally similar molecules present in other pathogens will be discussed and highlighted for their importance as potential therapeutic targets.

Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens / R. Rhome, T. Mcquiston, T. Kechichian, A. Bielawska, M. Hennig, M. Drago, G. Morace, C. Luberto, M. Del Poeta. - In: EUKARYOTIC CELL. - ISSN 1535-9778. - 6:10(2007 Oct), pp. 1715-1726.

Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens

M. Drago;G. Morace;
2007

Abstract

This review summarizes the current understanding of the role of sphingolipid biosynthesis in the pathobiology of cryptococcosis, focusing on the production and functions of the antigenic glycosphingolipid (GSL) glucosylceramide (GlcCer) and its role in the host-pathogen interaction. In addition, the presence of GlcCer and structurally similar molecules present in other pathogens will be discussed and highlighted for their importance as potential therapeutic targets.
English
Settore MED/07 - Microbiologia e Microbiologia Clinica
Review essay
Esperti anonimi
Ricerca di base
Pubblicazione scientifica
ott-2007
American Society for Microbiology
6
10
1715
1726
12
Pubblicato
Periodico con rilevanza internazionale
Aderisco
info:eu-repo/semantics/article
Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens / R. Rhome, T. Mcquiston, T. Kechichian, A. Bielawska, M. Hennig, M. Drago, G. Morace, C. Luberto, M. Del Poeta. - In: EUKARYOTIC CELL. - ISSN 1535-9778. - 6:10(2007 Oct), pp. 1715-1726.
reserved
Prodotti della ricerca::01 - Articolo su periodico
9
262
Article (author)
si
R. Rhome, T. Mcquiston, T. Kechichian, A. Bielawska, M. Hennig, M. Drago, G. Morace, C. Luberto, M. Del Poeta
File in questo prodotto:
File Dimensione Formato  
EukCell2007.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 190.46 kB
Formato Adobe PDF
190.46 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/33449
Citazioni
  • ???jsp.display-item.citation.pmc??? 22
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 29
social impact