Streptomyces M281 produces, in aerated liquid cultures, a substance which has been extracted and purified. The antibiotic M281 inhibits the growth of Saccharomyces cerevisiae in glycerol-containing media, but not in those containing glucose. It has been proved that M281 induces respiratory-deficient (RD) phenocopies with high efficiency. The antibiotic inhibits succinate dehydrogenase and possibly some other enzyme between succinate dehydrogenase and cytochrome c.
A novel metabolite producing respiratory deficient phenocopies in Saccharomyces cerevisiae / G. Lucchini Bonomini, C. Frova, L. Panzeri, M. Paternioster, M. Cocucci. - In: PLANT SCIENCE LETTERS. - ISSN 0304-4211. - 7:2(1976), pp. 109-117.
A novel metabolite producing respiratory deficient phenocopies in Saccharomyces cerevisiae
M. CocucciUltimo
1976
Abstract
Streptomyces M281 produces, in aerated liquid cultures, a substance which has been extracted and purified. The antibiotic M281 inhibits the growth of Saccharomyces cerevisiae in glycerol-containing media, but not in those containing glucose. It has been proved that M281 induces respiratory-deficient (RD) phenocopies with high efficiency. The antibiotic inhibits succinate dehydrogenase and possibly some other enzyme between succinate dehydrogenase and cytochrome c.
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