MeCP2 is associated with several neurological disorders; of which, Rett syndrome undoubtedly represents the most frequent. Its molecular roles, however, are still unclear, and data from animal models often describe adult, symptomatic stages, while MeCP2 functions during embryonic development remain elusive. We describe the pattern and timing of Mecp2 expression in the embryonic neocortex highlighting its low but consistent expression in virtually all cells and show the unexpected occurrence of transcriptional defects in the Mecp2 null samples at a stage largely preceding the onset of overt symptoms. Through the deregulated expression of ionic channels and glutamatergic receptors, the lack of Mecp2 during early neuronal maturation leads to the reduction in the neuronal responsiveness to stimuli. We suggest that such features concur to morphological alterations that begin affecting Mecp2 null neurons around the perinatal age and become evident later in adulthood. We indicate MeCP2 as a key modulator of the transcriptional mechanisms regulating cerebral cortex development. Neurological phenotypes of MECP2 patients could thus be the cumulative result of different adverse events that are already present at stages when no obvious signs of the pathology are evident and are worsened by later impairments affecting the central nervous system during maturation and maintenance of its functionality.

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms / F. Bedogni, C. Cobolli Gigli, D. Pozzi, R.L. Rossi, L. Scaramuzza, G. Rossetti, M. Pagani, C. Kilstrup Nielsen, M. Matteoli, N. Landsberger. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - (2015 May 15). [Epub ahead of print] [10.1093/cercor/bhv078]

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms

M. Pagani;M. Matteoli;N. Landsberger
2015

Abstract

MeCP2 is associated with several neurological disorders; of which, Rett syndrome undoubtedly represents the most frequent. Its molecular roles, however, are still unclear, and data from animal models often describe adult, symptomatic stages, while MeCP2 functions during embryonic development remain elusive. We describe the pattern and timing of Mecp2 expression in the embryonic neocortex highlighting its low but consistent expression in virtually all cells and show the unexpected occurrence of transcriptional defects in the Mecp2 null samples at a stage largely preceding the onset of overt symptoms. Through the deregulated expression of ionic channels and glutamatergic receptors, the lack of Mecp2 during early neuronal maturation leads to the reduction in the neuronal responsiveness to stimuli. We suggest that such features concur to morphological alterations that begin affecting Mecp2 null neurons around the perinatal age and become evident later in adulthood. We indicate MeCP2 as a key modulator of the transcriptional mechanisms regulating cerebral cortex development. Neurological phenotypes of MECP2 patients could thus be the cumulative result of different adverse events that are already present at stages when no obvious signs of the pathology are evident and are worsened by later impairments affecting the central nervous system during maturation and maintenance of its functionality.
No
English
MeCP2 null cortex; embryonic cerebral cortex development; intrinsic neuronal excitability; neurological disorders; transcriptome
Settore BIO/11 - Biologia Molecolare
Articolo
Esperti anonimi
Ricerca di base
Pubblicazione scientifica
15-mag-2015
Oxford University Press
Epub ahead of print
Periodico con rilevanza internazionale
pubmed
crossref
Aderisco
info:eu-repo/semantics/article
Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms / F. Bedogni, C. Cobolli Gigli, D. Pozzi, R.L. Rossi, L. Scaramuzza, G. Rossetti, M. Pagani, C. Kilstrup Nielsen, M. Matteoli, N. Landsberger. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - (2015 May 15). [Epub ahead of print] [10.1093/cercor/bhv078]
none
Prodotti della ricerca::01 - Articolo su periodico
10
262
Article (author)
no
F. Bedogni, C. Cobolli Gigli, D. Pozzi, R.L. Rossi, L. Scaramuzza, G. Rossetti, M. Pagani, C. Kilstrup Nielsen, M. Matteoli, N. Landsberger
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/326530
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