In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ER(LBA) content compared to patients with high-ER(LBA) tumours. These findings indicate that tumour progression, activated or sustained by high VEGF levels, may be counteracted in high-ER(LBA) cancers by tamoxifen, which in contrast fails to contrast the metastatic potential in low-ER(LBA) tumours.
Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen / D. Coradini, E. Biganzoli, C. Pellizzaro, S. Veneroni, S. Oriana, F. Ambrogi, R. Erdas, P. Boracchi, M.G. Daidone, E. Marubini. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 89:2(2003 Jul 21), pp. 268-270.
Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
E. BiganzoliSecondo
;F. Ambrogi;P. Boracchi;E. MarubiniUltimo
2003
Abstract
In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ER(LBA) content compared to patients with high-ER(LBA) tumours. These findings indicate that tumour progression, activated or sustained by high VEGF levels, may be counteracted in high-ER(LBA) cancers by tamoxifen, which in contrast fails to contrast the metastatic potential in low-ER(LBA) tumours.Pubblicazioni consigliate
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