Background: It has been recently demonstrated that in Frontotemporal Lobar Degeneration (FTLD) memory deficits at presentation are commoner than previously thought. Apolipoprotein E ( ApoE) genotype, the major genetic risk factor in sporadic late-onset Alzheimer Disease ( AD), modulates cerebral perfusion in late middle-age cognitively normal subjects. ApoE epsilon 4 homozygous have reduced glucose metabolism in the same regions involved in AD. The aim of this study was to determine whether ApoE genotype might play a key-role in influencing the cerebral functional pattern as well as the degree of memory deficits in FTLD patients. Methods: Fifty-two unrelated FTLD patients entered the study and underwent a somatic and neurological evaluation, laboratory examinations, a brain structural imaging study, and a brain functional Single Photon Emission Tomography study. ApoE genotype was determined. Results: ApoE genotype influenced both clinical and functional features in FTLD. ApoE epsilon 4-carriers were more impaired in long-term memory function (ApoE epsilon 4 vs. ApoE non epsilon 4, 6.3 +/- 3.9 vs. 10.1 +/- 4.2, p = 0.004) and more hypoperfused in uncus and parahippocampal regions ( x, y, z = 38,- 6,- 20, T = 2.82, cluster size = 100 voxels; - 32,- 12,- 28, T = 2.77, cluster size = 40 voxels). Conclusion: The present findings support the view that ApoE genotype might be considered a disease-modifying factor in FTLD, thus contributing to define a specific clinical presentation, and might be of relevance for pharmacological approaches.

Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration / B. Borroni, D. Perani, S. Archetti, C. Agosti, B. Paghera, G. Bellelli, M.M.G. Di Luca, A. Padovani. - In: BMC NEUROLOGY. - ISSN 1471-2377. - 6(2006 Aug), pp. 31.31.1-31.31.6.

Functional correlates of Apolipoprotein E genotype in Frontotemporal Lobar Degeneration

M.M.G. Di Luca
Penultimo
;
2006

Abstract

Background: It has been recently demonstrated that in Frontotemporal Lobar Degeneration (FTLD) memory deficits at presentation are commoner than previously thought. Apolipoprotein E ( ApoE) genotype, the major genetic risk factor in sporadic late-onset Alzheimer Disease ( AD), modulates cerebral perfusion in late middle-age cognitively normal subjects. ApoE epsilon 4 homozygous have reduced glucose metabolism in the same regions involved in AD. The aim of this study was to determine whether ApoE genotype might play a key-role in influencing the cerebral functional pattern as well as the degree of memory deficits in FTLD patients. Methods: Fifty-two unrelated FTLD patients entered the study and underwent a somatic and neurological evaluation, laboratory examinations, a brain structural imaging study, and a brain functional Single Photon Emission Tomography study. ApoE genotype was determined. Results: ApoE genotype influenced both clinical and functional features in FTLD. ApoE epsilon 4-carriers were more impaired in long-term memory function (ApoE epsilon 4 vs. ApoE non epsilon 4, 6.3 +/- 3.9 vs. 10.1 +/- 4.2, p = 0.004) and more hypoperfused in uncus and parahippocampal regions ( x, y, z = 38,- 6,- 20, T = 2.82, cluster size = 100 voxels; - 32,- 12,- 28, T = 2.77, cluster size = 40 voxels). Conclusion: The present findings support the view that ApoE genotype might be considered a disease-modifying factor in FTLD, thus contributing to define a specific clinical presentation, and might be of relevance for pharmacological approaches.
Settore BIO/14 - Farmacologia
ago-2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/30179
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