Low plasma concentrations of docosahexaenoic acid (DHA) are reported in unsupplemented cystic fibrosis (CF) patients. Forty-one CF patients aged from 6 to 12 years were randomized to receive high-dose DHA (100 mg/kg/day in the first month and 1g per day thereafter through a 12-month supplementation) or placebo (germ oil). Primary outcome was percentage change in plasma AA:DHA ratio. Secondary outcomes were changes in the number of pulmonary exacerbations compared to previous year, lung function, BMI, skinfold thicknesses, and body composition assessed by DXA and in serum concentrations of C-reactive protein, cytokines and vitamin (α-tocopherol and retinol). Compared to the control group plasma AA:DHA ratio decreased in the intervention group after 6 months (median percentage changes: -73% in the intervention group vs. -10% in the control group, P=0.001). No differences were detected between groups for secondary outcomes. Despite a decrease of the AA/DHA ratio, DHA supplementation for one year did not induce any significant biochemical and clinical improvement in CF patients.
|Titolo:||A randomized placebo-controlled stuidy on high-dose oral algal docosahexaenoic acid supplementation in children with custic fibrosis|
|Parole Chiave:||Cystic fibrosis; Docosahexaenoic acid; Supplementation; Plasma fatty acids; Randomised clinical trial|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||feb-2013|
|Data ahead of print / Data di stampa:||21-dic-2012|
|Digital Object Identifier (DOI):||10.1016/j.plefa.2012.10.002|
|Appare nelle tipologie:||01 - Articolo su periodico|