Resveratrol (trans-3,4’,5-trihydroxystilbene) has attracted the attention of the biomedical researchers because of its beneficial physiological effects it produces. Positive effects of resveratrol has been observed in the field of cardiovascular diseases and neurodegenerative disorders. It has been also identified as a potent cancer chemopreventive agent in assays representing the three major stages of carcinogenesis (i.e. tumor initiation, promotion and progression). We have synthesized a variety of Resveratrol analogues by chemical modification of the parent trihydroxy stilbene skeleton. The compounds were screened for cancer chemopreventive potential using a series of bioassays relevant for the prevention of carcinogenesis in humans (inhibition of cytochrome P450 1A; determination of NAD(P)H:quinone reductase activity; scavenging of radicals; inhibition of cyclooxygenase activity; inhibition of NO synthase; antiestrogenic and estrogenic activity).

Synthesis of novel derivatives of resveratrol and screening for potential cancer chemopreventive activities / F. Orsini, R. Pagliarin, L. Verotta, C. Gerhauser, K. Klimo. ((Intervento presentato al 24. convegno Congresso Nazionale della Societa' Chimica Italiana tenutosi a Lecce nel 2011.

Synthesis of novel derivatives of resveratrol and screening for potential cancer chemopreventive activities

F. Orsini
Primo
;
R. Pagliarin
Secondo
;
L. Verotta;
2011

Abstract

Resveratrol (trans-3,4’,5-trihydroxystilbene) has attracted the attention of the biomedical researchers because of its beneficial physiological effects it produces. Positive effects of resveratrol has been observed in the field of cardiovascular diseases and neurodegenerative disorders. It has been also identified as a potent cancer chemopreventive agent in assays representing the three major stages of carcinogenesis (i.e. tumor initiation, promotion and progression). We have synthesized a variety of Resveratrol analogues by chemical modification of the parent trihydroxy stilbene skeleton. The compounds were screened for cancer chemopreventive potential using a series of bioassays relevant for the prevention of carcinogenesis in humans (inhibition of cytochrome P450 1A; determination of NAD(P)H:quinone reductase activity; scavenging of radicals; inhibition of cyclooxygenase activity; inhibition of NO synthase; antiestrogenic and estrogenic activity).
set-2011
resveratrol; chemoprevention; drug metabolism, aromatase, cyclooxygenase, Nrf2, iNOS
Settore CHIM/06 - Chimica Organica
Settore BIO/10 - Biochimica
Universita' del Salento
Federchimica
Synthesis of novel derivatives of resveratrol and screening for potential cancer chemopreventive activities / F. Orsini, R. Pagliarin, L. Verotta, C. Gerhauser, K. Klimo. ((Intervento presentato al 24. convegno Congresso Nazionale della Societa' Chimica Italiana tenutosi a Lecce nel 2011.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/292061
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