A set of novel 1-aryl-6,7-methylenedioxy-3 H-quinazolin-4-(thi)ones (3a–f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed.
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents / M. Zappalà, S. Grasso, N. Micale, G. Zuccalà, F.S. Menniti, G. Ferreri, G. De Sarro, C. De Micheli. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 13:24(2003 Dec 15), pp. 4427-4430. [10.1016/j.bmcl.2003.09.032]
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents
C. De MicheliUltimo
2003
Abstract
A set of novel 1-aryl-6,7-methylenedioxy-3 H-quinazolin-4-(thi)ones (3a–f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed.
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