Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity.

Brain-derived neurotrophic factor : a bridge between inflammation and neuroplasticity / F. Calabrese, A.C. Rossetti, G. Racagni, P. Gass, M.A. Riva, R. Molteni. - In: FRONTIERS IN CELLULAR NEUROSCIENCE. - ISSN 1662-5102. - 8(2014 Dec 22), pp. 430.1-430.7. [10.3389/fncel.2014.00430]

Brain-derived neurotrophic factor : a bridge between inflammation and neuroplasticity

F. Calabrese
Primo
;
A.C. Rossetti
Secondo
;
G. Racagni;M.A. Riva
Penultimo
;
R. Molteni
Ultimo
2014

Abstract

Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system. For this, their expression in both systems is under a tight regulatory control. However, pathological conditions may lead to an overproduction of pro-inflammatory cytokines that may have a detrimental impact on central nervous system. In particular, they may damage neuronal structure and function leading to deficits of neuroplasticity, the ability of nervous system to perceive, respond and adapt to external or internal stimuli. In search of the mechanisms by which pro-inflammatory cytokines may affect this crucial brain capability, we will discuss one of the most interesting hypotheses: the involvement of the neurotrophin brain-derived neurotrophic factor (BDNF), which represents one of the major mediators of neuroplasticity.
BDNF; depression; lipopolysaccaride; neurogenesis; pro-inflammatory cytokines; cellular and molecular neuroscience
Settore BIO/14 - Farmacologia
22-dic-2014
Article (author)
File in questo prodotto:
File Dimensione Formato  
Fr Cell Neurosci 2014.pdf

accesso aperto

Descrizione: Articolo
Tipologia: Publisher's version/PDF
Dimensione 431.45 kB
Formato Adobe PDF
431.45 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/286684
Citazioni
  • ???jsp.display-item.citation.pmc??? 145
  • Scopus 349
  • ???jsp.display-item.citation.isi??? 321
social impact