The concept of convergent synthesis can be extended to combinatorial chemistry in order to obtain collections of products characterized by considerable chemical diversity and a certain molecular complexity. In this work, a library consisting of three carboxylic acids containing a benzimidazolonic functionality with variations at two positions was synthesized on solid phase. After cleavage, this library was combined with a second library consisting of 16 solid-supported amines containing two points of variation. IRORI technology was used for the split-and-mix synthesis of the final 48 members library.

Solid-phase convergent synthesis of a benzoimidazolone library via the combination of two smaller arrays of carboxylic acids and secondary amines / I. Bianchi, E. La Porta, D. Barlocco, L.F. Raveglia. - In: JOURNAL OF COMBINATORIAL CHEMISTRY. - ISSN 1520-4766. - 6:5(2004), pp. 835-845.

Solid-phase convergent synthesis of a benzoimidazolone library via the combination of two smaller arrays of carboxylic acids and secondary amines

D. Barlocco
Penultimo
;
2004

Abstract

The concept of convergent synthesis can be extended to combinatorial chemistry in order to obtain collections of products characterized by considerable chemical diversity and a certain molecular complexity. In this work, a library consisting of three carboxylic acids containing a benzimidazolonic functionality with variations at two positions was synthesized on solid phase. After cleavage, this library was combined with a second library consisting of 16 solid-supported amines containing two points of variation. IRORI technology was used for the split-and-mix synthesis of the final 48 members library.
Settore CHIM/08 - Chimica Farmaceutica
2004
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/28196
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