New unconventional beta and gamma dipeptides, representing conformationally constrained higher homologues of glutamic acid, have been prepared and tested as new pharmacological tools to investigate the iGluR binding domain, in an attempt to identify potential selective antagonists.
Synthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligands / L. Tamborini, F. Mastronardi, F. Dall'Oglio, C. De Micheli, B. Nielsen, L. Lo Presti, P. Conti, A. Pinto. - In: MEDCHEMCOMM. - ISSN 2040-2503. - 6:7(2015 Jul), pp. 1260-1266. [10.1039/C5MD00159E]
Synthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligands
L. Tamborini
Primo
;F. MastronardiSecondo
;F. Dall'Oglio;C. De Micheli;L. Lo Presti;P. ContiPenultimo
;A. PintoUltimo
2015
Abstract
New unconventional beta and gamma dipeptides, representing conformationally constrained higher homologues of glutamic acid, have been prepared and tested as new pharmacological tools to investigate the iGluR binding domain, in an attempt to identify potential selective antagonists.
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