OBJECTIVE: To examine the incidence of major cerebral abnormalities on postnatal imaging in cases with isolated mild ventriculomegaly on fetal sonography and to evaluate the relationship between the presence or absence of such defects and prenatal ultrasound factors. METHODS: We searched our databases to identify all cases with mild ventriculomegaly (10-15 mm) and no other major structural abnormalities on prenatal ultrasound, with normal karyotype and no evidence of maternal or fetal infection. For each case we retrieved data on prenatal ultrasound follow-up, fetal magnetic resonance imaging (MRI), neonatal ultrasound and/or brain MRI and pregnancy outcome. RESULTS: Postnatal imaging revealed a major cerebral abnormality in 9 (6.9%) of 130 liveborns with isolated mild ventriculomegaly on prenatal ultrasound. In 6 (66.7%) of 9 cases the abnormality was known or suspected prenatally on fetal MRI. Multivariate analysis showed that the only significant contribution to the prediction of major cerebral abnormalities was provided by persistence or progression of ventricular enlargement on serial ultrasound examinations (p = 0.001, OR 21.1 [95%CI: 3.6-122.7]). CONCLUSION: Prenatal ultrasound follow-up identifies fetuses at higher risk for a major cerebral abnormality among cases with isolated mild ventriculomegaly. In cases with persistent or progressive enlargement fetal MRI and postnatal imaging seem appropriate.

Prenatal ultrasound predictors of postnatal major cerebral abnormalities in fetuses with apparently isolated mild ventriculomegaly / G.M. Baffero, F. Crovetto, I. Fabietti, S. Boito, R. Fogliani, M. Fumagalli, F. Triulzi, F. Mosca, L. Fedele, N. Persico. - In: PRENATAL DIAGNOSIS. - ISSN 0197-3851. - 35:8(2015), pp. 783-788.

Prenatal ultrasound predictors of postnatal major cerebral abnormalities in fetuses with apparently isolated mild ventriculomegaly

M. Fumagalli;F. Triulzi;F. Mosca;L. Fedele
Penultimo
;
N. Persico
2015

Abstract

OBJECTIVE: To examine the incidence of major cerebral abnormalities on postnatal imaging in cases with isolated mild ventriculomegaly on fetal sonography and to evaluate the relationship between the presence or absence of such defects and prenatal ultrasound factors. METHODS: We searched our databases to identify all cases with mild ventriculomegaly (10-15 mm) and no other major structural abnormalities on prenatal ultrasound, with normal karyotype and no evidence of maternal or fetal infection. For each case we retrieved data on prenatal ultrasound follow-up, fetal magnetic resonance imaging (MRI), neonatal ultrasound and/or brain MRI and pregnancy outcome. RESULTS: Postnatal imaging revealed a major cerebral abnormality in 9 (6.9%) of 130 liveborns with isolated mild ventriculomegaly on prenatal ultrasound. In 6 (66.7%) of 9 cases the abnormality was known or suspected prenatally on fetal MRI. Multivariate analysis showed that the only significant contribution to the prediction of major cerebral abnormalities was provided by persistence or progression of ventricular enlargement on serial ultrasound examinations (p = 0.001, OR 21.1 [95%CI: 3.6-122.7]). CONCLUSION: Prenatal ultrasound follow-up identifies fetuses at higher risk for a major cerebral abnormality among cases with isolated mild ventriculomegaly. In cases with persistent or progressive enlargement fetal MRI and postnatal imaging seem appropriate.
natural-history; fetal; guidelines; diagnosis; outcomes; atrium; width
Settore MED/38 - Pediatria Generale e Specialistica
2015
Article (author)
File in questo prodotto:
File Dimensione Formato  
FumagalliPersicoPrenDiagn2015.pdf

accesso riservato

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 277.1 kB
Formato Adobe PDF
277.1 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Baffero_et_al-2015-Prenatal_Diagnosis.pdf

accesso riservato

Descrizione: Articolo principale
Tipologia: Publisher's version/PDF
Dimensione 93.38 kB
Formato Adobe PDF
93.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/275090
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 31
social impact