The aim of this study was to evaluate two combinations of propofol and dexmedetomidine for induction of general anaesthesia in dogs. Twenty-seven dogs (ASA I-II) were assigned into two groups. Baseline values for HR, PR, ECG, fR, MAP, SAP, DAP and body temperature were recorded. Both groups received a rapid bolus of propofol (2.2 mg kg)1 IV) immediately followed by rapid bolus of dexmedetomidine: 2 lg kg)1 IV (group A) or 3 lg kg)1 IV (group B). Quality of induction, intubation time and adverse effects were recorded. Measurements were repeated 1, 2, 5, 10, 15 minutes after drug administration with the addition of PE¢CO2, SpO2, sedation score and painful stimulus test (Fernandez et al. 2005). Data were analyzed using ANOVA with repeated measures (physiological variables) and Mann–Whitney U test (sedation and analgesia) (p < 0.05). Induction quality, sedation score and intubation time (A: 1.8 ± 1.12 minutes, B: 2.5 ± 1.72 minutes) were similar between groups. Heart rate decreased after drug administration (A: 115 ± 19 to 69 ± 18, B: 109 ± 20 to 59 ± 17) as did fR (A: 66 ± 15 to 16 ± 7, B: 59 ± 19 to 21 ± 5). Both variables were not statistically different between groups but statistically lower than baseline in each group at each timepoint. Blood pressure was statistically higher in both groups than baseline levels at each timepoint (MAP: baseline A: 103 ± 22, B: 98 ± 14, after induction A: 127 ± 25, B: 111 ± 18). Body temperature and PE¢CO2 were similar, SpO2 was statistically higher in group B. No apnoea (>30 seconds) or emesis were recorded. No patients required additional propofol for intubation. Both protocols were effective in producing induction of general anaesthesia in healthy dogs, allowing intubation without significant side effects. Reference: Fernandez JG, Parodi E, Garcia P et al. (2005) Clinical action of subarachnoid sevoflurane in vivo: a study in dogs. British J Anaesth 95(4), 530–534.
Rapid injection of propofol and dexmedetomidine for induction of general anaesthesia in dogs : sedative, analgesic, haemodynamic and respiratory effects / L. Borghi, F. Brioschi, V. Bronzo, D. Fonda, G. Ravasio - In: Proceedings of the Spring meeting and Association of veterinary anaesthetists : AVA Spring meeting, Bari, Italy, 13th-15th April, 2011[s.l] : Association veterinary anaesthetists, 2011 Apr 13. - pp. 20-21 (( convegno Spring meeting of the Association of veterinary anaesthetists : AVA Spring meeting tenutosi a Bari nel 2011.
Rapid injection of propofol and dexmedetomidine for induction of general anaesthesia in dogs : sedative, analgesic, haemodynamic and respiratory effects
L. Borghi;F. Brioschi;V. Bronzo;D. Fonda;G. Ravasio
2011
Abstract
The aim of this study was to evaluate two combinations of propofol and dexmedetomidine for induction of general anaesthesia in dogs. Twenty-seven dogs (ASA I-II) were assigned into two groups. Baseline values for HR, PR, ECG, fR, MAP, SAP, DAP and body temperature were recorded. Both groups received a rapid bolus of propofol (2.2 mg kg)1 IV) immediately followed by rapid bolus of dexmedetomidine: 2 lg kg)1 IV (group A) or 3 lg kg)1 IV (group B). Quality of induction, intubation time and adverse effects were recorded. Measurements were repeated 1, 2, 5, 10, 15 minutes after drug administration with the addition of PE¢CO2, SpO2, sedation score and painful stimulus test (Fernandez et al. 2005). Data were analyzed using ANOVA with repeated measures (physiological variables) and Mann–Whitney U test (sedation and analgesia) (p < 0.05). Induction quality, sedation score and intubation time (A: 1.8 ± 1.12 minutes, B: 2.5 ± 1.72 minutes) were similar between groups. Heart rate decreased after drug administration (A: 115 ± 19 to 69 ± 18, B: 109 ± 20 to 59 ± 17) as did fR (A: 66 ± 15 to 16 ± 7, B: 59 ± 19 to 21 ± 5). Both variables were not statistically different between groups but statistically lower than baseline in each group at each timepoint. Blood pressure was statistically higher in both groups than baseline levels at each timepoint (MAP: baseline A: 103 ± 22, B: 98 ± 14, after induction A: 127 ± 25, B: 111 ± 18). Body temperature and PE¢CO2 were similar, SpO2 was statistically higher in group B. No apnoea (>30 seconds) or emesis were recorded. No patients required additional propofol for intubation. Both protocols were effective in producing induction of general anaesthesia in healthy dogs, allowing intubation without significant side effects. Reference: Fernandez JG, Parodi E, Garcia P et al. (2005) Clinical action of subarachnoid sevoflurane in vivo: a study in dogs. British J Anaesth 95(4), 530–534.
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