We studied the in vivo fate of CD8(+) lymphocytes, of naive (CD8(+)CD45RC(bright)) or memory (CD8(+)CD45RC(dim)) phenotype, injected in syngeneic rats, after their sorting and labeling with [(99m)Tc] HM-PAO. By using the scintigrafic method we showed that memory CD8(+) lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.
Distribution of 99mTc-labeled lymphocytes in control and inflamed rats / A. Fulgenzi, R. Casati, F.R. Colombo, M. Gasparini, E. Ferrero, A. Bondanza, P. Gerundini, M.E. Ferrero. - In: NUCLEAR MEDICINE AND BIOLOGY. - ISSN 0969-8051. - 31:5(2004 Jul), pp. 631-638.
Distribution of 99mTc-labeled lymphocytes in control and inflamed rats
A. FulgenziPrimo
;M.E. Ferrero
2004
Abstract
We studied the in vivo fate of CD8(+) lymphocytes, of naive (CD8(+)CD45RC(bright)) or memory (CD8(+)CD45RC(dim)) phenotype, injected in syngeneic rats, after their sorting and labeling with [(99m)Tc] HM-PAO. By using the scintigrafic method we showed that memory CD8(+) lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.
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