Introduction Phenolic compounds are known to have antioxidant properties mainly because they can act as free-radical scavengers since the hydroxyl groups can donate an electron or hydrogen atom to a free radical. Recently, phenolic compounds grafted onto the backbone of poly(lactide-co-glycolide) (PLGA) were proposed as novel biodegradable materials stable to sterilization by gamma- irradiation at the dose of 25 kGy [1]. Nevertheless, no information on the feasibility to encapsulate biological drug products have been available.
Preparation and characterization of caffeic acid grafted PLGA microspheres / F. Selmin, F. Puoci, O.I. Parisi, S. Franzé, U.M. Musazzi, P. Minghetti, F. Cilurzo. ((Intervento presentato al convegno Workshop of Controlled Release Society Italian Chapter: "Nanomedicine: pharmacokinetic challenges, targeting strategies and clinical outcomes" tenutosi a Firenze nel 2014.
Preparation and characterization of caffeic acid grafted PLGA microspheres
F. SelminPrimo
;S. Franzé;U.M. Musazzi;P. MinghettiPenultimo
;F. CilurzoUltimo
2014
Abstract
Introduction Phenolic compounds are known to have antioxidant properties mainly because they can act as free-radical scavengers since the hydroxyl groups can donate an electron or hydrogen atom to a free radical. Recently, phenolic compounds grafted onto the backbone of poly(lactide-co-glycolide) (PLGA) were proposed as novel biodegradable materials stable to sterilization by gamma- irradiation at the dose of 25 kGy [1]. Nevertheless, no information on the feasibility to encapsulate biological drug products have been available.
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