The hazard function plays an important role in the study of disease dynamics in survival analysis. Longer follow-up for various kinds of cancer, particularly breast cancer, has made it possible the observation of complex shapes of the hazard function of occurrence of metastasis and death. The identification of the correct hazard shape is important both for formulation and support of biological hypotheses on the mechanism underlying the disease. In this paper we propose the use of a neural network to model the shape of the hazard function in time in dependence of covariates extending the piecewise exponential model. The use of neural networks accommodates a greater flexibility in the study of the hazard shape.

Piecewise Exponential Artificial Neural Networks (PEANN) for Modeling Hazard Function with Right Censored Data / M. Fornili, F. Ambrogi, P. Boracchi, E. Biganzoli (LECTURE NOTES IN COMPUTER SCIENCE). - In: Computational Intelligence Methods for Bioinformatics and Biostatistics - 10th International Meeting, CIBB 2013, Nice, France, June 20-22, 2013, Revised Selected Papers[s.l] : Springer, 2014. - ISBN 978-3-319-09041-2. - pp. 125-136 [10.1007/978-3-319-09042-9_9]

Piecewise Exponential Artificial Neural Networks (PEANN) for Modeling Hazard Function with Right Censored Data

M. Fornili
Primo
;
F. Ambrogi
Secondo
;
P. Boracchi
Penultimo
;
E. Biganzoli
Ultimo
2014

Abstract

The hazard function plays an important role in the study of disease dynamics in survival analysis. Longer follow-up for various kinds of cancer, particularly breast cancer, has made it possible the observation of complex shapes of the hazard function of occurrence of metastasis and death. The identification of the correct hazard shape is important both for formulation and support of biological hypotheses on the mechanism underlying the disease. In this paper we propose the use of a neural network to model the shape of the hazard function in time in dependence of covariates extending the piecewise exponential model. The use of neural networks accommodates a greater flexibility in the study of the hazard shape.
Settore MED/01 - Statistica Medica
2014
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/252479
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